Prospects of a new antistaphylococcal drug batumin revealed by molecular docking and analysis of the complete genome sequence of the batumin-producer Pseudomonas batumici UCM B-321
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- 作者：Vitalii V. Klochkoa ; Liubov B. Zelenab ; Ju Young Kimc ; Lilia V. Avdeevaa ; Oleg N. Revac ; oleg.reva@up.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antistaphylococcal antibiotic ; Pseudomonas batumici ; Molecular docking ; Genome ; Batumin ; Mupirocin
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：47
- 期：1
- 页码：56-61
- 全文大小：881 K
文摘
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Batumin acts similarly to mupirocin by targeting aminoacyl tRNA synthetases.
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The genome of the batumin-producing strain Pseudomonas batumici was sequenced.
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The batumin operon was horizontally acquired together with batG and leuRS paralogues.
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The latter genes presumably confer batumin resistance in P. batumici.
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Dissimilar batumin/mupirocin resistance mechanisms allow improved MRSA therapy.
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