Discovery of estrogen receptor or estrophilin by Jensen in 1958.

Discovery of the three-domain structure of nuclear receptors in 1970’s by the Gustafsson Lab.

Discovery of specific DNA binding of the glucocorticoid receptor by Yamamoto and Gustafsson in 1981.

Cloning of the first (partial) cDNA of a nuclear receptor (the GR) by Yamamoto and Gustafsson in 1984.

Cloning of the full length GR by Evans in 1985.