Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment
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- 作者：Chun-Yen Chena ; b ; Yi-Wei Yehb ; Shin-Chang Kuoa ; b ; Pei-Shen Hoc ; Chih-Sung Lianga ; c ; Che-Hung Yena ; d ; Ru-Band Lue ; San-Yuan Huanga ; b ; hsy@ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：AR1 ; autoregression of an order-1 ; COMT ; catechol-O-methyltransferase ; DSM-IV-TR ; diagnostic and statistical manual of mental disorders ; fourth edition ; text revision ; LD ; linkage disequilibrium ; MMRM ; mixed model for repeated-measures ; PANSS ; positive and negative syndrome scale ; PFC ; prefrontal cortex ; SADS-L ; schedule of affective disorder and schizophrenia-lifetime ; SCZ ; schizophrenia ; SNP ; single nucleotide polymorphism
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：67-75
- 全文大小：767 K
文摘
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The COMT variants are associated with improvement of negative symptoms after amisulpride treatment.
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The COMT rs4680 variant is associated with the change of plasma prolactin levels after treatment.
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The variation in plasma prolactin levels might be a measurable biomarker of COMT variants and treatment outcomes.
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