Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length
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- 作者：Lucia Ya. Zakharovaa ; lucia@iopc.ru" class="auth_mail" title="E-mail the corresponding author ; luciaz@mail.ru" class="auth_mail" title="E-mail the corresponding author ; Dinar R. Gabdrakhmanova ; Alsu R. Ibragimovaa ; Elmira A. Vasilievaa ; Irek R. Nizameeva ; Marsil K. Kadirova ; Elena A. Ermakovab ; Natalia E. Gogolevab ; Dzhigangir A. Faizullinb ; Andrey G. Pokrovskyc ; Vladislav A. Korobeynikovc ; Sergey V. Cheresizc ; Yuriy F. Zuevb
- 关键词：Cationic surfactants ; DNA ; Complexation ; Lipid bilayer ; Transfection ; Transformation
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：269-277
- 全文大小：1342 K
文摘
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High transfection efficacy was demonstrated for DNA–hydroxyethylated gemini complexes.
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DNA–gemini complexation is controlled by a spacer length.
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Gemini with dodecamethylene spacer showed superior capacity of integrating with lipid bilayer.
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Gemini with dodecamethylene spacer demonstrated superior transfection efficacy.
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