The effect of constitutive over-expression of insulin-like growth factor 1 on the cognitive function in aged mice
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- 作者：Ankang Hua ; 1 ; Honghua Yuanb ; 1 ; Lianlian Wua ; Renjin Chena ; Quangang Chena ; Tengye Zhangb ; Zhenzhen Wangb ; Peng Liub ; Xiaorong Zhua ; zxr1967@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IGF-1 ; Aged mice ; Cognitive ability ; p-CaMKII ; p-ERK1/2 ; Hippocampus
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：204-213
- 全文大小：1923 K
文摘
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We prepared transgenic mice overexpressing IGF-1 specifically in neural stem cells.
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Overexpressed IGF-1 can mitigate the aged-related cognitive decline.
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CaMKII and ERK signaling pathway may relate to the aged-related cognitive decline.
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