Cytokines participate in the pathophysiology of depression.
Pro-inflammatory cytokines impair glucocorticoid receptor (GR) expression/function.
Alarin restores the cytokine levels altered in a mouse model of depression.
Alarin also reverses the decreased brain GR protein expression seen in this model.
Cytokines and GRs may mediate the antidepressant-like effect of alarin.
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