Acute exposure of mercury chloride stimulates the tissue regeneration program and reactive oxygen species production in the Drosophila midgut
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- 作者：Zhi Chen1 ; xiaolongzaishi@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiaochun Wu1 ; Hongjie Luo ; Lingling Zhao ; Xin Ji ; Xianfeng Qiao ; Yaping Jin ; Wei Liu ; wliucn150@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drosophila ; Mercury chloride ; Midgut ; ROS ; Vitamin E
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：32-38
- 全文大小：2338 K
文摘
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Mercury was largely sequestered within the midgut epithelia of Drosophila after oral administration.
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Mercury stimulation induced excess production of reactive oxygen species in the midgut epithelia.
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Mercury stimulation caused increased cell death.
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Mercury stimulation triggered tissue regeneration through accelerated proliferation and differentiation of intestinal stem cells.
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Vitamin E efficiently alleviated the HgCl2-induced tissue damages and improved the survival rate.
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