DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo
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- 作者：Guowei Zhang zhangguowei.2009@163.com" class="auth_mail" title="E-mail the corresponding author ; Kaijun Liu liu.kaijun@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xi Ling lingxi1024@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhi Wang 15098908000@163.com" class="auth_mail" title="E-mail the corresponding author ; Peng Zou julinlaotou@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaogang Wang happywinton@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianfang Gao 1571662230@qq.com" class="auth_mail" title="E-mail the corresponding author ; Li Yin yingli198609@163.com" class="auth_mail" title="E-mail the corresponding author ; Xi Zhang zxzx126@163.com" class="auth_mail" title="E-mail the corresponding author ; Jinyi Liu jinyiliutmmu@163.com" class="auth_mail" title="E-mail the corresponding author ; Lin Ao ; aolin117@163.com" class="auth_mail" title="E-mail the corresponding author ; Jia Cao ; caojia1962@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DBP ; dibutyl phthalate ; ER ; endoplasmic reticulum ; UPR ; unfolded protein response ; IRE1α ; inositol-requiring protein-1α ; PERK ; protein kinase RNA (PKR)-like ER kinase ; ATF-4 ; activating transcription factor 4 ; ATF-6 ; activating transcription factor 6 ; CHOP ; transcription factor C/EBP homologous protein ; LC3 ; microtubule-associated protein 1 light chain 3 ; 4-PBA ; 4-phenylbutyrate ; 3-MA ; 3-methyladenine ; TEM ; transmission electron microscopy
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：86-98
- 全文大小：4316 K
文摘
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DBP exposure induced apoptosis both in vitro, in GC-2 cells, and in vivo, in prepubertal rat testis germ cells.
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DBP induced ER stress in germ cells both in vitro and in vivo.
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ER stress-mediated CHOP activation contributed to DBP-induced germ cell apoptosis.
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DBP-induced ER stress also triggered autophagy, which has a protective effect against germ cell death.
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