Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences
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- 作者：Aswin Mangericha ; 1 ; Malgorzata Debiaka ; 1 ; 3 ; Matthias Birtela ; 1 ; Viviane Ponatha ; Frank Balszuweitb ; Kirsten Lexa ; 4 ; Rita Martelloa ; 5 ; Waltraud Burckhardt-Boera ; Romano Strobeltb ; Markus Siegertb ; Horst Thiermannb ; Dirk Steinritzb ; c ; Annette Schmidtb ; 2 ; Alexander Bü ; rklea ; 2 ; alexander.buerkle@uni-konstanz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Poly(ADP-ribose) ; PARP inhibitors ; Sulfur mustard ; Nitrogen mustard ; Genotoxicity ; HaCaT ; Mass spectrometry ; Micronucleus
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：26 February 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：56-71
- 全文大小：3619 K
文摘
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Detailed analysis of sulfur and nitrogen mustard-induced PARylation in HaCaT cells
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PARylation participates in mustard-induced stress response in a substance-specific manner
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PARP inhibitors potentiate CEES-induced genome instability
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With limitations, CEES and HN2 can be used as surrogates to study SM-related toxicity
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PARP inhibitors should be considered with caution as SM antidotes, due to potential long-term effects
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