Enantioselective synthesis of preclavulone A and its methyl ester

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• 作者：Alessio Porta ; Savino Re ; Giuseppe Zanoni ; Giovanni Vidari
• 关键词：Preclavulone A ; Marine clavulones ; Enantioselective synthesis ; Julia olefination
• 刊名：Tetrahedron
• 出版年：2007
• 出版时间：7 May 2007
• 年：2007
• 卷：63
• 期：19
• 页码：3989-3994
• 全文大小：237 K

文摘

A highly enantioselective synthesis of the (8S,12S)-enantiomer of preclavulone A and its methyl ester is described featuring the Julia protocol for installing the (Z)-double bond in the lower chain. This procedure is suitable for the preparation of labeled preclavulone analogues for biosynthetic studies on marine clavulones.