Construction and immune protection evaluation of recombinant polyvalent OmpAs derived from genetically divergent ompA by DNA shuffling
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- 作者：Hui Li ; lihui32@sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiao Chu ; Dan Li ; Zao-hai Zeng ; Xuan-xian Peng ; pxuanx@sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polyvalent vaccine ; Vibrio alginolyticus ; Edwardsiella tarda ; Aquaculture ; DNA shuffling
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：230-236
- 全文大小：3030 K
文摘
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DNA shuffling is used to create a new hybrid OmpA with improved cross-protection.
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EompAs-19 is demonstrated as an ideal polyvalent vaccine.
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EompAs-19 prevents fish from infections caused Vibrio alginolyticus and Edwardsiella tarda.
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EOmpAs-19 had three mutations, which are a molecular basis as a polyvalent vaccine.
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