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Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1
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文摘

During myogenesis, Smyd1 expression is temporally downstream of Myogenin.

Deletion of Smyd1 from myoblasts results in less muscle fibers.

First wave myogenesis appears unaffected, but second wave myogenesis is impaired.

Smyd1 affects late stage myoblast differentiation.

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