Early adventitial activation characterized by NADPH oxidase expression and neovascularization in an aortic transplantation model
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- 作者：Mengyao Suna ; 1 ; sunmyhappy@163.com" class="auth_mail" title="E-mail the corresponding author ; Jian Jia ; b ; 1 ; jijian1981@gmail.com" class="auth_mail" title="E-mail the corresponding author ; jijian@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaotong Guoa ; 761746150@qq.com" class="auth_mail" title="E-mail the corresponding author ; Wenjun Liua ; 18560081165@163.com" class="auth_mail" title="E-mail the corresponding author ; Yanyan Wangc ; 156085820@qq.com" class="auth_mail" title="E-mail the corresponding author ; Siqin Mad ; zhuzhu292929@163.com" class="auth_mail" title="E-mail the corresponding author ; Weicheng Hua ; huweicheng@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jianli Wanga ; wangmaq@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fan Jianga ; fjiang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TV ; transplant vasculopathy ; ERK ; extracellular signal-regulated kinase ; VEGF ; vascular endothelial growth factor ; ROS ; reactive oxygen species ; F344 ; Fischer 344 rat ; Lew ; Lewis rat ; AF ; Adventitial Fibroblast ; Lipo ; Lipofectmin
- 刊名：Experimental and Molecular Pathology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：100
- 期：1
- 页码：67-73
- 全文大小：1276 K
文摘
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Adventitial thickening was one of the earliest events occurring before the development of intimal hyperplasia after aortic transplantation.
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NADPH oxidase expression was increased in the macrophage and fibroblasts of graft adventitia.
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Neovascularization in the adventitia correlated with neointima formation.
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Knockingdown NADPH oxidase expression inhibited proliferation and migration of adventitial fibroblasts.
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