FDG uptake was significantly higher in squamous cell carcinomas (mean SUV 13.4 ± 4.9, n = 8) compared to adenocarcinomas (7.1 ± 3.3, n = 8, p = 0.007), or large cell carcinomas (5.9 ± 1.9, n = 3, p = 0.02). The degree of FDG accumulation seemed to depend especially on GLUT-1, GLUT-3 and tumor cell differentiation. The summed standardized values of these three parameters correlated significantly with the SUV (r = 0.47, p = 0.05).
The present study supports the hypothesis that tumor cell differentiation in combination with overexpression of GLUT-1 and GLUT-3 determine the extent of FDG accumulation and that squamous cell carcinomas accumulate more FDG than adenocarcinomas or large cell carcinomas.
FDG uptake, glucose transporter type 1, and Ki European Journal of Radiology |
FDG uptake, glucose transporter type 1, and Ki European Journal of Radiology, Volume 62, Issue 2, May 2007, Pages 214-219 Xuan Canh Nguyen, Won Woo Lee, Jin-Haeng Chung, So Yeon Park, Sook Whan Sung, Yu Kyeong Kim, Young So, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Sang Eun Kim Abstract PurposeFDG uptake mediated by glucose transporter type 1 (Glut-1) and tumor proliferative activity assessed by Ki-67 expression provide prognostic information in patients with non-small-cell lung cancer (NSCLC). Here, we compared the prognostic significances of FDG uptake, and of Glut-1 and Ki-67 expressions in patients with NSCLC.MethodsNSCLC patients (n = 53, F:M = 16:37, age 61.9 ± 12.1 years) who underwent curative resection after FDG-PET were enrolled. Thirty-one patients had stage I, 15 stage II, and 7 stage III disease. Patients were treated by surgery only (n = 12), surgery plus adjuvant oral chemotherapy (n = 32), or surgery plus adjuvant intravenous chemo- or radio-therapy (n = 9). Maximum standardized FDG uptake values (maxSUV), and the Glut-1 and Ki-67 expressions of resected tumors were analyzed for correlations and relations with tumor recurrence. The median follow-up duration was 15 months. ResultsThirteen (24.5 % ) of the 53 patients experienced recurrence during a median follow-up of 8 months and significant correlations were found between maxSUV, Glut-1, and Ki-67 expressions (r = 0.48–0.79, p < 0.001). Univariate analysis revealed that disease-free survival (DFS) was significantly correlated with maxSUV (<7 versus ≥7, p = 0.001), % Ki-67 expression (<25 % versus ≥25 % , p = 0.047), tumor size (<3 cm versus ≥3 cm, p = 0.027), and tumor cell differentiation (well/moderate versus poor, p = 0.011). However, multivariate Cox proportional analysis identified maxSUV as the only determinant of DFS (p = 0.005). Patients with a maxSUV of ≥7 (n = 14) had a significantly lower 1-year DFS rate (57.1 % ) than those with a maxSUV of <7 (n = 39, 89.7 % ). ConclusionFDG uptake is more valuable than Glut-1 or Ki-67 expression in terms of predicting prognosis in patients with resected NSCLC. Purchase PDF (281 K) |
FDG uptake and glucose transporter type 1 expression in... European Journal of Surgical Oncology |
FDG uptake and glucose transporter type 1 expression in lymph nodes of non European Journal of Surgical Oncology, Volume 32, Issue 9, November 2006, Pages 989-995 J.-H. Chung, W.W. Lee, S.Y. Park, G. Choe, S.W. Sung, J.-K. Chung, M.C. Lee, S.E. Kim Abstract AimsFDG uptake in NSCLC is related to glucose transporter type 1 (Glut-1) expression. Here, we investigated the direct causal relationship between FDG uptake and Glut-1 expression to determine the role of Glut-1 in FDG uptake by malignant and benign lymph nodes (LNs).MethodsFifty-five curative lung resections in 53 NSCLC patients (male:female = 36:17, age = 62.0 ± 11.8 years) were included. Maximum standardized uptake values (maxSUVs) of LNs in preoperative whole body FDG-PET and Glut-1 immunostaining results were compared. ResultsOf 316 pathologically confirmed LNs, 12.3 % (39/316) were malignant, and in malignant LNs, FDG positive LNs were no different from FDG negative LNs in terms of size (15.0 ± 6.7 mm vs 10.0 ± 6.1 mm, p > 0.05), or in terms of the proportion of LNs occupied by tumor (60.0 ± 28.8 % vs 39.2 ± 38.4 % , p > 0.05), but had greater percentages of Glut-1 positive cells in tumors (74.1 ± 31.8 % vs 22.7 ± 18.7 % , p < 0.01), and Glut-1 staining intensities (3.4 ± 0.9 vs 1.8 ± 1.3, p < 0.01). FDG negative malignant LNs featured cytoplasmic Glut-1 expression and adenocarcinoma. Glut-1 staining intensities were found to be significantly correlated with the maxSUVs of malignant LNs (ρ = 0.516, p < 0.05), but the percentages of Glut-1 positive cells in tumors were not (r = 0.2072, p > 0.05). Analysis of FDG positive benign LNs showed that maxSUV was not correlated with degree of follicular hyperplasia, or Glut-1 expression (p > 0.05). ConclusionsIntense Glut-1 immunoreactivity was found to be proportionally related to the degree of FDG uptake by malignant LNs in NSCLC. However, the finding that Glut-1 expression in lymphoid hyperplasia showed no correlation with FDG uptake in benign LNs requires further investigation. Purchase PDF (1080 K) |
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