Mean first involuntary detrusor contraction volume on standard cystometry was 162.9 ± 96.4 ml. and it was 232.1 ± 115.3 ml. during posterior tibial nerve stimulation. Mean maximum cystometric capacity on standard cystometry was 221 ± 129.5 ml. and it was 277.4 ± 117.9 ml. during stimulation. Posterior tibial nerve stimulation was associated with significant improvement in first involuntary detrusor contraction volume (p <0.0001) and significant improvement in maximum cystometric capacity (p <0.0001). The test was considered positive in 22 of the 44 patients.
These results suggest an objective acute effect of posterior tibial nerve stimulation on urodynamic parameters. Improved bladder overactivity is an encouraging argument to propose posterior tibial nerve stimulation as a noninvasive treatment modality in clinical practice.
Extracorporeal Magnetic Stimulation is of Limited Clini... European Urology |
Extracorporeal Magnetic Stimulation is of Limited Clinical Benefit to Women with Idiopathic Detrusor Overactivity: A Randomized Sham Controlled Trial European Urology, Volume 52, Issue 3, September 2007, Pages 876-883 Alastair R. Morris, Ray O'Sullivan, Paula Dunkley, Kate H. Moore Abstract ObjectivesTo observe the effect of both acute and medium-term magnetic stimulation of the pelvic floor on detrusor function amongst women with idiopathic detrusor overactivity (IDO).MethodsTwo separate studies were undertaken amongst women with a sole diagnosis of IDO. The first study assessed the acute effect of magnetic stimulation (provided by Neocontrol®) on detrusor function during the filling phase of standard cystometry. Multiple filling cycles were performed with stimulation at a different key moment in each. This was done to establish that the device could influence the detrusor. Subsequently, a randomized sham control trial was performed to assess clinical efficacy. A total of 20 treatments, each of 20 minutes duration, were administered over six weeks with follow-up six weeks thereafter. Half the patients received therapy from a genuine device, the others receiving fake treatment on an identical looking/sounding sham device. The sham device contained a deflector plate to degrade the magnetic field and was located in a separate room. Outcome measures included changes in a 24 hour fluid volume chart, urine loss (24 hour pad test) and quality of life instruments. ResultsAmongst 10 patients receiving stimulation during cystometry, volume at first involuntary detrusor contraction during filling rose from a median value of 240 ml (Inter-quartile range (IQR) 210–300) to 285 ml (IQR 231–320), p = 0.03 and maximum detrusor pressure decreased from 40 cm water (IQR 34–45) to 33 cm water (IQR 25–41), p < 0.01. The RCT was completed by 29 of 44 (66 % ) recruits. Of these, 15 of 29 (52 % ) received active treatment and 14 of 29 (48 % ) sham therapy. Active therapy significantly reduced the number of urge episodes per day, p < 0.01. With respect to baseline, actively treated patients experienced significant reduction in voids per day and quality of life but this trend did not reach significance when compared to the sham group, partly due to unexpected difficulty in recruitment which yielded an underpowered sample size for these outcome measures. ConclusionsMagnetic stimulation reduces detrusor contractility in the acute phase of administration. Although the treatment was well tolerated and urge episodes reduced following prolonged therapy, no statistically significant improvement was observed in quality of life indices or measured 24 hour urinary loss. The treatment cannot be recommended for women with IDO. Purchase PDF (215 K) |
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