Quantitative measures of meniscus extrusion predict incident radiographic knee osteoarthritis - data from the Osteoarthritis Initiative

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• 作者：K. Emmanuel^&dagger ; ; ^&Dagger ; ; ^{katja.emmanuel@bhs.at" class="auth_mail" title="E-mail the corresponding author} ; E. Quinn^§ ; ; J. Niu^§ ; ; A. Guermazi^‖ ; ^¶ ; ; F. Roemer^‖ ; ^# ; W. Wirth^&dagger ; ; ^&dagger ; &dagger ; ; F. Eckstein^&dagger ; ; ^&dagger ; &dagger ; ; D. Felson^§ ; ; ^&Dagger ; &Dagger ;
• 关键词：Meniscus position ; Meniscus extrusion ; Incident knee osteoarthritis ; Meniscus position risk factor for knee osteoarthritis
• 刊名：Osteoarthritis and Cartilage
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：24
• 期：2
• 页码：262-269
• 全文大小：433 K

文摘

To test the hypothesis that quantitative measures of meniscus extrusion predict incident radiographic knee osteoarthritis (KOA), prior to the advent of radiographic disease.

Methods

206 knees with incident radiographic KOA (Kellgren Lawrence Grade (KLG) 0 or 1 at baseline, developing KLG 2 or greater with a definite osteophyte and joint space narrowing (JSN) grade ≥1 by year 4) were matched to 232 control knees not developing incident KOA. Manual segmentation of the central five slices of the medial and lateral meniscus was performed on coronal 3T DESS MRI and quantitative meniscus position was determined. Cases and controls were compared using conditional logistic regression adjusting for age, sex, BMI, race and clinical site. Sensitivity analyses of early (year [Y] 1/2) and late (Y3/4) incidence was performed.

Results

Mean medial extrusion distance was significantly greater for incident compared to non-incident knees (1.56 mean ± 1.12 mm SD vs 1.29 ± 0.99 mm; +21%, P < 0.01), so was the percent extrusion area of the medial meniscus (25.8 ± 15.8% vs 22.0 ± 13.5%; +17%, P < 0.05). This finding was consistent for knees restricted to medial incidence. No significant differences were observed for the lateral meniscus in incident medial KOA, or for the tibial plateau coverage between incident and non-incident knees. Restricting the analysis to medial incident KOA at Y1/2 differences were attenuated, but reached significance for extrusion distance, whereas no significant differences were observed at incident KOA in Y3/4.

Conclusion

Greater medial meniscus extrusion predicts incident radiographic KOA. Early onset KOA showed greater differences for meniscus position between incident and non-incident knees than late onset KOA.