ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
详细信息 查看全文
- 作者：Hui Zhang1 ; PamelaSara E. Head1 ; Waaqo Daddacha1 ; Seong-Hoon Park2 ; Xingzhe Li1 ; Yunfeng Pan1 ; Matthew Z. Madden1 ; Duc M. Duong3 ; Maohua Xie1 ; Bing Yu1 ; Matthew D. Warren1 ; Elaine A. Liu1 ; Vishal R. Dhere1 ; Chunyang Li1 ; Ivan Pradilla1 ; Mylin A. Torres1 ; Ya Wang1 ; William S. Dynan1 ; 3 ; Paul W. Doetsch1 ; 3 ; Xingming Deng1 ; Nicholas T. Seyfried3 ; David Gius2 ; David S. Yu1 ; dsyu@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：sirtuin ; metabolism ; SIRT2 ; ATR ; ATRIP ; replication stress ; DNA replication ; DNA damage response ; DNA repair ; acetylome ; cell cycle ; checkpoint
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：14
- 期：6
- 页码：1435-1447
- 全文大小：3084 K
文摘
- •
SIRT2 interacts with and deacetylates ATRIP at K32 in vitro and in cells
- •
ATRIP deacetylation by SIRT2 promotes ATR activation and replication stress recovery
- •
ATRIP deacetylation by SIRT2 promotes accumulation to sites of DNA damage
- •
SIRT2 deacetylation of ATRIP at K32 promotes its direct binding to RPA-ssDNA
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |