Transmission of influenza A in human beings

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• 作者：Julian W Tang ; Yuguo Li
• 关键词：Knee ; Genu recurvatum ; Deformity ; Brothers ; Osteoarthritis
• 刊名：The Lancet Infectious Diseases
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：7
• 期：12
• 页码：758
• 全文大小：37 K

文摘

Pneumococcal conjugate vaccines (PCVs) are a potentially useful complement to existing treatment strategies in HIV-infected children, for whom pneumococcal infections are common and serious. This Review summarises available data on the burden of pneumococcal disease and the safety and efficacy of PCVs in HIV-infected children. The data demonstrate that children with HIV have significantly increased risk of pneumococcal disease compared with uninfected children; the serotypes included in currently licensed or near-licensure conjugate vaccines include most serotypes that cause invasive pneumococcal disease (IPD) in HIV-infected children and adults; PCVs provide substantial protection against IPD and clinical pneumonia when given to HIV-infected infants; and HIV-infected adults gain an indirect benefit when children in the community are vaccinated. PCV should be considered as an important intervention for improving the lives of HIV-infected children.