In vivo virulence of viral haemorrhagic septicaemia virus (VHSV) in rainbow trout Oncorhynchus mykiss correlates inversely with in vitro Mx gene expression
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- 作者：Irene Canoa ; irene.canocejas@cefas.co.uk" class="auth_mail" title="E-mail the corresponding author ; Bertrand Colletb ; Clarissa Pereiraa ; Richard Paleya ; Ronny van Aerlea ; David Stonea ; Nick G.H. Taylora
- 关键词：Viral haemorrhagic septicaemia virus ; Pathogenicity ; Mx ; Viral fitness ; RTG-P1 ; Luciferase ; Inhibition
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：187
- 期：Complete
- 页码：31-40
- 全文大小：715 K
文摘
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Virulent VHSV isolates to rainbow trout showed higher infective titre and higher viral N gene expression than avirulent isolates.
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Marine VHSV isolates from genotypes Ib and II induced higher expression of rainbow trout Mx1/3 gene than the virulent isolates.
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When co-inoculated with J167 (Ia) the Ib and II isolates induced significantly less Mx1/3 up-regulation.
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J167 inhibited Mx1 isoform gene expression in RTG-2 and RTgill-1 cells.
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Mx gene expression in the transgenic RTG-P1 cell line showed a J167 dose-dependent inhibition.
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