Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia
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- 作者：Andrea Leivaa ; aaleiva@uc.cl" class="auth_mail" title="E-mail the corresponding author ; Bá ; rbara Fuenzalidaa ; Rocí ; o Salsosoa ; d ; Eric Barrosa ; Fernando Toledoa ; b ; Jaime Gutié ; rreza ; c ; Fabiá ; n Pardoa ; Luis Sobreviaa ; d ; e ; sobrevia@med.puc.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：MPH ; maternal physiological hypercholesterolemia ; MSPH ; maternal supraphysiological hypercholesterolemia ; GTP ; guanosine triphosphate ; GTPCH1 ; GTP cyclohydrolase 1 ; DHFR ; dihydrofolate reductase ; BH2 ; dihydrobiopterine ; BH4 ; tetrahydrobiopterine ; HUVECs ; human umbilical vein endothelial cells ; TCh ; total cholesterol ; LDL ; low density lipoprotein ; vLDL ; very-low density lipoprotein ; HDL ; high-density lipoprotein ; NO ; nitric oxide ; eNOS ; endothelial nitric oxide synthase ; CGRP ; calcitonine gene re
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：536-544
- 全文大小：1294 K
文摘
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MSPH associates with reduced umbilical vein dilation.
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HUVECs from MSPH show reduced BH4 synthesis.
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The substrate for BH4 synthesis, sepiapterin, reverses MSPH-reduced vein dilation.
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Reduced BH4 synthesis leads to lower NO synthesis and bioavailability in HUVECs.
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MSPH-associated alterations may determine in uterus foetal vascular programming.
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