Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1
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- 作者：Syouichi Katayamaa ; Yukako Sengaa ; b ; Ami Oia ; Yosuke Mikia ; Yasunori Sugiyamaa ; Noriyuki Sueyoshia ; Isamu Kameshitaa ; kamesita@ag.kagawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amph1 ; amphiphysin 1 ; BAR ; Bin-Amphiphysin-Rvs ; CDKL5 ; cyclin-dependent kinase-like 5 ; CLAP ; clathrin/AP-2 binding ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DMEM ; Dulbecco's modified Eagle's medium ; Dnmt1 ; DNA methyltransferase 1 ; GST ; glutathione S-transferase ; hpf ; hours post-fertilization ; MeCP2 ; methyl CpG-binding protein 2 ; PSD-95 ; postsynaptic density-95 ; PRD ; proline-rich domain ; RT-PCR ; reverse-transcription PCR ; SH3 ; src homology-3
- 刊名：Gene
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：583
- 期：1
- 页码：15-23
- 全文大小：3294 K
文摘
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Two splice variants of CDKL5 were cloned from a zebrafish cDNA library.
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Three variants of amphiphysin 1 (Amph1), a possible target of CDKL5, were obtained.
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Amph1 variants were significantly phosphorylated by CDKL5.
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Colocalization of zebrafish CDKL5 and Amph1 was observed in living cells.
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Variants of CDKL5 and Amph1 showed different spatial and temporal expressions.
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