IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma
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- 作者：Felix Beuschleina ; 1 ; Judith Jakobyb ; 1 ; Susanne Mentza ; Gerard Zambettic ; Sara Junga ; Martin Reinckea ; Regine Sü ; ssb ; 1 ; Constanze Hantela ; 1 ; Constanze.Hantel@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adrenocortical carcinoma ; Liposomal doxorubicin ; Immunoliposomes ; Caelyx® ; NCI-H295R ; SJ-ACC3 ; MUC-1
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：428
- 期：Complete
- 页码：82-88
- 全文大小：1667 K
文摘
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We established novel approaches of IGF-1 receptor inhibition and liposomal doxorubicin for therapeutic treatment of adrenocortical carcinoma.
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We investigated therapeutic responsiveness in three different xenograft models for ACC (NCI-H295R, SJ-ACC3, MUC-1).
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Our experiments indicate, that implementation of this panel of tumor models might be helpful for clinical translation in the future.
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