Genetic variants in multisynthetase complex genes are associated with DNA damage levels in Chinese populations
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- 作者：Jia Liua ; 1 ; Meng Zhua ; 1 ; Weihong Chenb ; 1 ; Kaipeng Xiea ; Wei Shena ; Jing Yuanb ; Yang Chenga ; Liguo Genga ; Yuzhuo Wanga ; Guangfu Jina ; Juncheng Daia ; Hongxia Maa ; Jiangbo Dua ; Meilin Wangc ; Zhengdong Zhangc ; Zhibin Hua ; 2 ; Tangchun Wub ; 2 ; Hongbing Shena ; 2 ; hbshen@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PM2.5 ; DNA damage ; Genetic variants ; MSC genes
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：786
- 期：Complete
- 页码：8-13
- 全文大小：743 K
文摘
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This is the first study investigating the association of variants in MSC genes and DNA damage level.
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Subjects were from three cities with different exposure level and a meta-analysis across the three cities was used.
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We evaluate the joint effects of SNPs on DNA damage levels in each of the city.
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We provide plausible explanation for the results using public database.
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