Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases

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• 作者：Pei-Jie Chen^a ; ^b ; Shuang-Peng Cai^a ; ^b ; Cheng Huang^a ; ^b ; Xiao-Ming Meng^a ; ^b ; Jun Li^a ; ^b ; ^{lj@ahmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{peijiechen@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：PTKs ; protein tyrosine kinases ; PTPs ; protein tyrosine phosphatases ; PTP1B ; protein tyrosine phosphatase 1B ; NAFLD ; non-alcoholic fatty liver disease ; HCC ; hepatocellular carcinoma ; DSPs ; dual specificity phosphatases ; LMW ; low molecular weight ; RPTPs ; transmembrane receptor-like PTPs ; NRPTPs ; nonreceptor-like PTPs ; MKPs ; mitogen-activated protein kinase phosphatases ; PRLs ; pTyr-specific phosphatases of regenerating liver ; PIP3 ; phosphatidylinositol-(3 ; 4 ; 5)-triphosphate ; LMPTP ; low molecular wei
• 刊名：Toxicology
• 出版年：2015
• 出版时间：4 November 2015
• 年：2015
• 卷：337
• 期：Complete
• 页码：10-20
• 全文大小：1912 K

文摘

Phosphorylation of tyrosine residues within proteins, which is controlled by the reciprocal action of protein tyrosine kinases and protein tyrosine phosphatases, plays a key role in regulating almost all physiological responses. Therefore, it comes as no surprise that once the balance of tyrosine phosphorylation is disturbed, drastic effects can occur. Protein tyrosine phosphatase 1B (PTP1B), a classical non-transmembrane tyrosine phosphatase, is a pivotal regulator and promising drug target in type 2 diabetes and obesity. Recently it has received renewed attention in liver diseases and represents an intriguing opportunity as a drug target by modulating hepatocyte death and survival, hepatic lipogenesis and so on. Here, the multiple roles of PTP1B in liver diseases will be presented, with respect to liver regeneration, drug-induced liver disease, non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma.