A novel DNA biosensor integrated with Polypyrrole/streptavidin and Au-PAMAM-CP bionanocomposite probes to detect the rs4839469 locus of the vangl1 gene for dysontogenesis prediction
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- 作者：Qingying Li1 ; Chao Yu1 ; Rufei Gao ; Chunyong Xia ; Guolin Yuan ; Yuliang Li ; Yilin Zhao ; Qiutong Chen ; Junlin He ; hejunlin_11@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PPy/ streptavidin ; Au-PAMAM ; Capture probe ; DNA biosensor
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：674-681
- 全文大小：5368 K
文摘
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A novel DNA biosensor to detect the rs4839469 locus of vangl1 gene for dysontogenesis prediction has been developed for the first time.
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PPy/streptavidin, which as modified matrix material, and Au-PAMAM-CP nanocomposite probe, a novel probe, were used for the rs4839469 locus of vangl1 gene detection.
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Wide linear range, good specificity and high sensitivity of the sensor have been achieved.
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