Modified chitosan thermosensitive hydrogel enables sustained and efficient anti-tumor therapy via intratumoral injection
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- 作者：Yingchun Jiang ; Xuanyu Meng ; Zhenghong Wu ; zhenghongwu66@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaole Qi ; qixiaole523@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paclitaxel ; Chitosan ; Thermosensitive hydrogel ; Mechanical strength ; Cyclodextrins ; Localized delivery
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：25 June 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：245-253
- 全文大小：2394 K
文摘
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Chitosan hydrogel was modified by polyvinyl alcohol and glutaraldehyde.
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The modified CS hydrogel showed a fine thermosensitive property.
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The mechanical strength of the modified CS hydrogel was highly improved.
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PTX loaded modified hydrogel showed a sustained drug release profile.
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Superior anti-tumor efficiency of PTX-loaded modified hydrogels was verified.
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