A chemical profiling solution for Chinese medicine formulas using comprehensive and loop-based multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
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- 作者：Xue Qiaoa ; 1 ; Qi Wanga ; 1 ; Wei Songa ; Yi Qiana ; Yao Xiaob ; Rong Anb ; De-an Guoa ; Min Yea ; yemin@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; yeminpku@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：2DLC/qTOF-MS ; Comprehensive 2DLC ; Multiple heart-cutting 2DLC ; Chinese medicine formula ; Gegen-Qinlian Decoction
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：1438
- 期：Complete
- 页码：198-204
- 全文大小：1905 K
文摘
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We describe a novel chemical profiling solution for complex matrix based on 2DLC.
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Comprehensive and MHC 2DLC/qTOF-MS methods were combined for the first time.
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The TCM formula Gegen-Qinlian Decoction was analyzed as a case.
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RP × RP stationary phase and acidic × alkaline mobile phase were applied.
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125 and additional 13 compounds were identified by comprehensive and MHC modes.
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