Investigation of the binding of cis/trans-[MCl₄(1H-indazole)(NO)]^{∿/sup> (M = Ru, Os) complexes to human serum albumin}

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• 作者：Orsolya D&ouml ; m&ouml ; t&ouml ; r^a ; ^b ; Anna Rathgeb^c ; Paul-Steffen Kuhn^c ; Ana Popović-Bijelić^d ; ^{ana@ffh.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author} ; Goran Bačić^d ; Eva Anna Enyedy^a ; ^{enyedy@chem.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Vladimir B. Arion^c ; ^{vladimir.arion@univie.ac.at" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nitrosyl ; Antitumor activity ; Albumin binding ; Fluorometry ; EPR spin labeling
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：159
• 期：Complete
• 页码：37-44
• 全文大小：651 K

文摘

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d="p0005">Cis/trans-[M(Cl)₄(1H-indazole)(L)]⁻ (M: Ru/Os; L: NO/CO) complexes were studied

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d="p0010">Moderately strong binding of the mononitrosyl complexes to human serum albumin

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d="p0015">Binding to both drug sites, I and II, of albumin

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d="p0020">Fatty acid displacement by the Ru mononitrosyl complex observed by EPR spin labeling

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d="p0025">Rapid decomposition of the monocarbonyl complex in aqueous solution

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