Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation

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• 作者：Florian ; Maria ; Lu ; Yan ; Angle ; Mark ; Magder ; Sheldon
• 关键词：PI(3)kinase ; Cerebral microvessels ; Flow-mediated dilation ; Wortmannin ; Hormones
• 刊名：Steroids
• 出版年：2004
• 出版时间：September, 2004
• 年：2004
• 卷：69
• 期：10
• 页码：637-645
• 全文大小：265 K

文摘

Acute administration of estrogen results in vasodilation and increased nitric oxide (NO) production. We examined the hypothesis that this is due to activation of Akt/PKB which subsequently increases eNOS activity.