Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

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• 作者：Kang ; Dae Gill ; Lee ; Yong Sup ; Kim ; Hyoung Ja ; Lee ; Yun Mi ; Lee ; Ho Sub
• 关键词：Clerodendron trichotomum ; Phenylpropanoid glycosides ; Angiotensin converting enzyme inhibitor ; Antihypertensive
• 刊名：Journal of Ethnopharmacology
• 出版年：2003
• 出版时间：November, 2003
• 年：2003
• 卷：89
• 期：1
• 页码：151-154
• 全文大小：76.6 K

文摘

The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan. Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside (<b>1b>), leucosceptoside A (<b>2b>), martynoside (<b>3b>), acteoside isomer (<b>4b>), and isomartynoside (<b>5b>). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides (<b>1b>–<b>5b>) in a dose-dependent manner of which ICb>50b> values were 373±9.3μg/ml, 423±18.8μg/ml, 524±28.1μg/ml, 376±15.6μg/ml, 505±26.7μg/ml, respectively. These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides.