PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P
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- 作者：Bin Huanga ; Shun Jun Fub ; Wen Zhe Fanc ; Zhong Hua Wangd ; Ze Bin Chena ; Sheng Jie Guoe ; Jun Xing Chena ; junxingchen@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Shao Peng Qiua ; qiushpmed@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein kinase C epsilon ; Side population cells ; Cancer stem cell ; ABCB1 ; Renal cell carcinoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：376
- 期：1
- 页码：148-154
- 全文大小：1607 K
文摘
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This study is to unravel the function of PKCɛ in SP cells of renal cell carcinoma.
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Knockdown of PKCε suppresses SP cell sorting in the 769P cell line.
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Knockdown of PKCε suppresses cancer stem cell phenotype of 769P SP cells.
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PKCε suppresses 769P SP cell sorting by negatively activating ABCB1 transporter.
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PKCε regulates stemness of 769P SP cells via PI3K/Akt and MAPK/ERK pathways.
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