A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS
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- 作者：Yihua Xu ; Xin-ce Huang ; Shengjie Dai ; Yuwu Xiao ; Meng-tao Zhou ; zmt0417@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bosutinib ; Rat ; UPLC-MS/MS ; Plasma ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：1004
- 期：Complete
- 页码：93-97
- 全文大小：475 K
文摘
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A method was fully validated to determine bosutinib in rat plasma.
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This is the most sensitive analysis for bosutinib.
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The plasma sample was prepared by a protein precipitation.
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Bosutinib was analyzed in rat plasma up to 48 h after administration.
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