Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage
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- 作者：Nurmaa Dashzeveg ; Satomi Yogosawa ; Kiyotsugu Yoshida ; kyoshida@jikei.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PKCδ ; protein kinase C delta ; ADR ; adriamycine ; BS ; binding site ; ns siRNA ; non-silencing siRNA ; CRISPRi ; clustered regularly interspaced short palindromic repeat interference ; dCAS9 ; dead Cas9 ; sgRNA ; single guide RNA ; wt-p53 / PKCδ ; wild type p53 / PKCδ ; mt-PKCδ / p53 ; mutant PKCδ / p53
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 April 2016
- 年：2016
- 卷：374
- 期：1
- 页码：167-174
- 全文大小：863 K
文摘
- 10">
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10">Transcriptional regulator of protein kinase C delta (PKCδ) is investigated in the human cancer cell lines.
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15">PKCδ is induced by p53 upon genotoxic stress.
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p53 controls apoptosis through PKCδ in a positive feedback mechanism.
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Induction of PKCδ is promising therapeutic target of mutant p53 bearing cancers.
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