Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 supports diagnosis and prognosis of PDAC-associated diabetes mellitus
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- 作者：Stefania Moza ; Daniela Bassob ; daniela.basso@sanita.padova.it" class="auth_mail" title="E-mail the corresponding author ; Andrea Padoana ; Dania Bozzatoa ; Paola Fogarb ; Carlo-Federico Zambona ; Michela Pellosoa ; Cosimo Spertic ; Saula Vigili de Kreutzenberga ; Claudio Pasqualic ; Sergio Pedrazzolid ; Angelo Avogaroa ; Mario Plebania ; b
- 关键词：Matrix metalloproteinases ; S100 proteins ; Pancreatic cancer ; Biliary tract cancer ; Type 2 diabetes mellitus
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：456
- 期：Complete
- 页码：24-30
- 全文大小：629 K
文摘
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PBMCs express MMP8 and MMP9 which are inducible by the S100A8 and S100A9.
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MMP9 expression reflects the presence of PDAC-associated diabetes mellitus.
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PDAC-derived PBMCs express high MMP8 and low S100A9 transcript levels.
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The expression of S100A9, not those of MMPs, are of prognostic relevance in PDAC.
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