GnRH receptor signalling to ERK: kinetics and compartmentalization

详细信息    查看全文

• 作者：Christopher James Caunt ; Ann R. Finch ; Kathleen R. Sedgley and Craig A. McArdle
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：17
• 期：8
• 页码：308-313
• 全文大小：294 K

文摘

Many hormones, neurotransmitters and growth factors influence their target cells by activation of mitogen-activated protein kinase cascades. The consequences of such activation reflect not only the magnitude, but also the kinetics and cellular compartmentalization of kinase activity. Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, a structure present in all other seven-transmembrane receptors. Here, we review spatiotemporal aspects of extracellular-signal-regulated kinase activation by gonadotropin-releasing hormone receptors, emphasizing how the absence or presence of the carboxyl-terminal tail dictates the receptors’ ability to engage and signal via arrestins.