Glycemic, insulinemic, and breath hydrogen responses to pullulan in healthy humans

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• 作者：Julie K. Spears ; Lisa K. Karr-Lilienthal ; Christine M. Grieshop ; Elizabeth A. Flickinger ; Bryan W. Wolf and George C. Fahey ; Jr.
• 关键词：Breath hydrogen ; Glycemic response ; Humans ; Insulinemic response ; Pullulan
• 刊名：Nutrition Research
• 出版年：2005
• 出版时间：December 2005
• 年：2005
• 卷：25
• 期：12
• 页码：1029-1041
• 全文大小：504 K

文摘

The objective of this study was to evaluate the glycemic, insulinemic, and breath hydrogen responses of healthy adult humans to low–molecular weight pullulan (molecular weight = 6300). Subjects (n = 34) consumed 50 g of maltodextrin or low–molecular weight pullulan in a randomized, double-masked, crossover design. Plasma glucose and serum insulin responses were determined over 180 minutes, and breath hydrogen response was determined for 8 hours. Low–molecular weight pullulan did not improve glucose response, but a reduction (P < .05) in serum insulin at 30, 60, and 90 minutes was noted. Peak insulin and area under the curve were reduced (P < .05) by 23 % and 20 % , respectively. Breath hydrogen increased (P < .05) at 4, 5, 6, 7, and 8 hours. Although low–molecular weight pullulan does not impact glycemia per se, it may reduce insulin response, resulting in decreased insulin concentrations in healthy adult humans.