Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system
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- 作者：Irina Gostimskaya ; Chris M. Grant ; chris.grant@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMS ; 4-acetamido-4&prime ; maleimidyldystilbene-2 ; 2&prime ; -disulphonic acid ; CLS ; chronological life span ; Cys ; cysteine ; dNTP ; deoxynucleotide ; ER ; endoplasmic reticulum ; Glr1 ; glutathione reductase 1 ; GSH ; reduced glutathione ; GSSG ; oxidized glutathione ; Gpx ; glutathione reductase 1 ; glutathione peroxidases ; Fe&ndash ; S ; iron&ndash ; sulphur ; MetO ; methionine sulphoxide ; OD600 ; optical density at 600  ; nm ; ONPG ; o-nitrophenyl-β-D-galactopyranoside ; OxD ; degree of probe oxidation ; ox ; oxidized ; R
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：55-65
- 全文大小：1708 K
文摘
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The mitochondrial glutathione redox state, but not the cytoplasmic glutathione redox state, is crucial for oxidant tolerance.
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The mitochondrial thioredoxin acts as a back-up antioxidant system for the glutathione system.
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Mitochondrial glutathione and thioredoxin play an overlapping role in redox regulation which is important during ageing and oxidative stress conditions.
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