PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy
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- 作者：Chounghun Kang ; Li Li Ji ; llji@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PGC-1α ; peroxisome proliferator-activated receptor gamma ; coactivator 1 alpha ; FoxO ; forkhead box O ; 4-HNE ; 4-hydroxynonenal ; Mul1 ; mitochondrial E3 ubiquitin protein ligase 1 ; PINK1 ; PTEN-induced putative kinase 1 ; Mfn2 ; mitofusin 2 ; mROS ; mitochondrial reactive oxygen species ; SOD2 ; superoxide dismutase 2 ; CS ; citrate synthase ; BNIP3 ; BCL2/adenovirus E1B 19 ; kDa interacting protein 3 ; LC3 ; microtubule-associated protein 1A/1B-light chain 3
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：32-40
- 全文大小：1624 K
文摘
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Muscle immobilization and remobilization up-regulate autophagy and mitophagy.
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PGC-1α protects the disused muscle from excessive catabolic degradation.
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PGC-1α attenuates mitophagy in muscle atrophy caused by immobilization.
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