Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2
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- 作者：Mingze Su ; Kuanhui Xiang ; Yao Li ; Yutang Li ; Juan Deng ; Xizhan Xu ; Ling Yan ; Hui Zhuang ; zhuangbmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Tong Li ; tongli08@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; amino acid ; ADV ; adefovir dipivoxil ; CHB ; chronic hepatitis B ; HBeAg ; hepatitis B e antigen ; HBsAg ; hepatitis B surface antigen ; HBV ; hepatitis B virus ; HIV ; human immunodeficiency virus ; HSPGs ; highly sulfated heparan sulfate proteoglycans ; LdT ; telbivudine ; LMV ; lamivudine ; MHR ; major hydrophilic region ; NAs ; nucleos(t)ide analogs ; NAr ; nucleos(t)ide analog resistance ; RT ; reverse transcriptase ; S ; surface
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：275-281
- 全文大小：865 K
文摘
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Mutation analysis was performed in subgenotype B2 HBV RT/S sequences of CHB patients.
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49.7% of RT and 33.6% of S sequences had substitutions at 74 studied AA sites.
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The rtN134D/S (30.8%) and sT126A/S (15.4%) were most frequently detected.
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RT/S substitutions were associated with lower serum HBV DNA and HBsAg levels.
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HBsAg level was negatively associated with S protein sequence substitution rate.
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