Effect of caspofungin and micafungin in combination with farnesol against Candida parapsilosis biofilms
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- 作者：Rená ; tó ; Ková ; csa ; kovacs.renato@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author ; Aliz Bozó ; a ; Rudolf Gesztelyib ; Marianna Domá ; na ; Gá ; bor Kardosa ; Fruzsina Nagya ; Zoltá ; n Tó ; tha ; Lá ; szló ; Majorosa
- 关键词：Echinocandin ; Time&ndash ; kill experiment ; Fractional inhibitory concentration index ; FICI ; Drug interaction ; Non-linear regression
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：47
- 期：4
- 页码：304-310
- 全文大小：914 K
文摘
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The interaction of farnesol and echinocandins against Candida parapsilosis biofilms was studied.
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FICIs, two methods based on Bliss independence, and time–kill experiments were used.
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Farnesol showed synergism with echinocandins against C. parapsilosis biofilms.
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Based on time–kill results, caspofungin + farnesol was effective even at 24 h.
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