IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

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• 作者：Michael Peine¹ ; ² ; Roman M. Marek¹ ; ² ; ³ ; Max Lö ; hning¹ ; ² ; ^{loehning@drfz.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：alarmin IL-33 ; ST2/T1/IL-1RL1 ; CD4+ and CD8+ T cell subsets ; Th1/Th2/Treg/CTL ; T-bet/GATA-3/Foxp3 ; STAT4/STAT5
• 刊名：Trends in Immunology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：37
• 期：5
• 页码：321-333
• 全文大小：2984 K

文摘

Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4⁺ and CD8⁺ T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3⁺ regulatory T cells in a GATA-3- and STAT5-dependent manner. Upon activation, Th1 and cytotoxic T cells express ST2 transiently, driven by T-bet and/or STAT4. We review these findings here, and critically examine evidence indicating that IL-33 enhances the differentiation and functionality of various T cell subsets through positive feedback loops involving lineage-specifying transcription factors. In this context, we discuss how quantitative and qualitative differences in ST2 expression between effector and GATA-3⁺ regulatory T cells may contribute to immune homeostasis, and outline important areas of future inquiry.