Collagen sponge from tilapia skin was extracted and proved to not induce obvious immune response.

Biomimetic electrospun tilapia collagen nanofibers with suitable tensile strength and thermal stability were developed.

The adhesion, proliferation and differentiation of HaCaTs were promoted by electrospun tilapia collagen nanofibers.

The electrospun tilapia collagen nanofibers could accelerate skin wound healing rapidly and effectively in the rat model.