We proposed a new strategy based on electrospray technique to prepare dual-responsive nanogels of pH and redox sensitive.

A biodegradable and multi-responsive poly(ether urethane) (PEU) was synthesized via a facile one-pot method and used as the electrospray material.

The electrospray dual-responsive nanogels may have potential to be a tumor-sensitive drug delivery system.

It demonstrated that the materials which can form hydrogels in physiological condition may be used to prepare nanogels by electrospray method.

It implies that the application range of these materials may be expanded with the more simple and efficient electrospray method for preparing nanogels.