In situ mineralization of anticancer drug into calcium carbonate monodisperse nanospheres and their pH-responsive release property
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- 作者：Tiezhu Yang ; Zhanghui Wan ; Zhiyuan Liu ; Haihong Li ; Hao Wang ; Nan Lu ; Zhenhua Chen<sup> ; sup><sup>zhchen561@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Xifan Mei <sup>meixifan1971@163.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Xiuli Ren <sup>rxlrenxiuli@163.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：CaCO3 ; Nanospheres ; Drug delivery ; pH-responsive ; Doxorubicin
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：384-392
- 全文大小：1776 K
文摘
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Monodisperse calcium carbonate nanospheres (~ 200 nm) encapsulated with doxorubicin was prepared.
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The preparation of CaCO<sub>3sub> nanospheres and the encapsulation of doxorubicin were facilitated in one step.
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Our strategy is a facile precipitation method for encapsulation of anticancer drug in water without any other organic agent.
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The release of doxorubicin from the nanospheres is pH responsive.
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