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Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex
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文摘

Cortical tubers of TSC are highly associated with intractable epilepsy.

TRPV4 and its upstream factor were clearly up-regulated in cortical tubers at the protein levels.

TRPV4 was specially distributed in abnormal cells, including dysplastic neurons and giant cells.

TRPV4 may be participated in the epileptogenicity of cortical tubers in TSC.

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