Alterations in the intrinsic electrophysiological properties of Purkinje neurons in a rat model of hepatic encephalopathy: Relative preventing effect of PPARγ agonist
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- 作者：Iraj Aghaeia ; iraj_8383@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Vahid Hajalib ; Ahmadreza Dehpourc ; Masoud Haghanid ; Vahid Sheibania ; Mohammad Shabania ; shabanimoh@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; shabani@kmu.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kynurenic acid (PubChem CID ; 3845) ; Pioglitazone hydrochloride (PubChem CID ; 60560) ; Picrotoxin (PubChem CID ; 531135)
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：16-25
- 全文大小：2743 K
文摘
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Bile duct ligation (BDL) alters Purkinje cells electrophysiological properties.
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Purkinje cells from BDL groups showed a significant increase in firing frequency.
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Pioglitazone (PIO) administration could contract BDL effects on PC firing frequency.
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BDL rats had an increased level of hepatic enzymes that was somewhat reversed by PIO.
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