Estradiol and angiotensin II crosstalk in hydromineral balance: Role of the ERK1/2 and JNK signaling pathways
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- 作者：G. Almeida-Pereiraa ; g.almeidapereira@gmail.com" class="auth_mail" title="E-mail the corresponding author ; R. Colettia ; A.S. Mecawib ; L.C. Reisb ; L.L.K. Eliasa ; J. Antunes-Rodriguesa
- 关键词：ANGII ; angiotensin II ; AT1 ; ANGII type 1 receptor ; AVP ; vasopressin ; DMSO ; dimethyl sulfoxide ; DUSPs ; dual-specificity phosphatases ; E2 ; estradiol ; ER ; estrogen receptor ; ERK1/2 ; extracellular-signal-regulated kinase ; GPCRs ; G-protein-coupled receptors ; icv ; intracerebroventricular ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinase family ; MKP-1 ; MAPK phosphatase 1 ; MnPO ; median preoptic nuclei ; OT ; oxytocin ; OVLT ; organum vasculosum of the lamina terminalis ; OVX ; ovariectomiz
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：525-538
- 全文大小：3648 K
文摘
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The effect of estradiol on ANGII-induced fluid intake requires the ERK1/2 and JNK signaling.
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JNK signaling is involved in fluid intake induced by ANGII in OVX rats.
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Estradiol therapy decreased ANGII-induced oxytocin and vasopressin secretion.
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The vasopressin secretion induced by ANGII requires ERK1/2 signaling in OVX rats.
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