Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-l-carnitine
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- 作者：Amir Baghaeia ; b ; Reza Solgic ; d ; Abbas Jafarie ; Amir Hossein Abdolghaffarif ; Alireza Golaghaeib ; Mohammad Hossein Asgharib ; Maryam Baeerib ; Seyed Nasser Ostadb ; Mohammad Sharifzadehb ; Mohammad Abdollahib ; Mohammad@TUMS.Ac.Ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetyl-l-carnitine ; Cytochrome c oxidase ; Oxidative stress ; Phosphine
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：30-37
- 全文大小：1328 K
文摘
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ALCAR attenuated phosphine-induced ROS production and oxidative stress.
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ALCAR reinforced cellular antioxidant power.
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ALCAR boosted ETC activity and ATP production.
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ALCAR inhibited phosphine-induced apoptosis and enhanced cell viability in cardiomyocytes.
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