The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte
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- 作者：Tamara Advedissiana ; 1 ; Fré ; dé ; rique Deshayesa ; 1 ; Franç ; oise Poiriera ; Mireille Viguiera ; Gilbert Richarmeb ; richarme@paris7.jussieu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carbonyl stress ; Glycation ; Maillard reaction ; Protein repair ; Diabetes ; Skin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：87-91
- 全文大小：728 K
文摘
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Glycation constitutes a covalent damage to proteins by reducing sugars and aldehydes.
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Parkinsonism-associated DJ-1/Park7 repairs proteins from glycation by glyoxals.
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We show that DJ-1 prevents protein glycation damage in keratinocytes.
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DJ-1 should be useful to prevent skin glycation and aging.
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Since glycation increases in diabetes, DJ-1 might prevent post-diabetic diseases.
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