ROCK inhibition abolishes the establishment of the aquiferous system in Ephydatia muelleri (Porifera, Demospongiae)
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- 作者：Quentin Schenkelaarsa ; b ; quentin.schenkelaars@unige.ch" class="auth_mail" title="E-mail the corresponding author ; Omar Quinteroc ; Chelsea Hallc ; Laura Fierro-Constaina ; Emmanuelle Renarda ; Carole Borchiellinia ; April L. Hillc ; ahill2@richmond.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porifera ; Ephydatia muelleri ; ROCK ; Development ; Y-27632 ; GSK429286A ; Morphogenesis
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：412
- 期：2
- 页码：298-310
- 全文大小：3173 K
文摘
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Bona fide components of the Rho/Rock pathway were identified in sponges.
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Y-27632 and GSK429286A inhibitors reduce the kinase activity of Em-ROCK in vitro.
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Early hatching gemmules treated with ROCK inhibitors show abnormal growth.
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Em-ROCK inhibition leads to the lack of aquiferous system.
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A cross-talk between Wnt, Rho/Rock and JNK/JUN is proposed here.
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